Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p359 | (1) | WCRB2014

Improvement of cloned blastocyst quality upon CHIR treatment of donor cells

Czernik Marta , Oikawa Mami , Iuso Domenico , Ogura Atsuo , Loi Pasqualino

Somatic cell nuclear transfer (SCNT) has a broad spectrum of many potential applications but the efficiency is still disappointingly low. It is known that major cause of it, is incorrect or incomplete reprogramming of the transferred donor nuclei.Many report indicates that Wnt/β-catenin signaling pathway plays a pivotal role in the process of somatic cell reprogramming. As CHIR is known as one of the activators of Wnt pathway by inhibiting glycogen ...